4'-Hydroxy-2,2-dimethylpropiophenone → HCID 58822987, compound

HRID 459385Notes

Reaction equation

HRID 459385 reaction equation
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[OH:20][C:21]1[CH:26]=[CH:25][C:24]([C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:23][CH:22]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:29][C:28]([CH3:31])([CH3:30])[C:27]([C:24]1[CH:23]=[CH:22][C:21]([O:20][CH2:15][CH2:14][O:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:17][CH3:18])[C:4]([OH:3])=[O:19])=[CH:12][CH:11]=2)=[CH:26][CH:25]=1)=[O:32]

Participants

4

Reactant 3

HCID 5780474'-Hydroxy-2,2-dimethylpropiophenoneHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

Product 1

HCID 58822987HCID 58822987, compound

Procedure

The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and 1-(4-hydroxy-phenyl)-2,2-dimethyl-propan-1-one via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a colorless oil. MS (ES) for C23H28O6 [M+H]+: 401.4.

Workup

  1. customto produce a colorless oil

Sources & evidence

ORD record
ord-cc7de26ad2b14eeea1b62ad4214672b9
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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