HCID 571860, compound → HCID 58822795, compound

HRID 459389Notes

Reaction equation

HRID 459389 reaction equation
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[OH:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28](=[O:35])[C:29]2[CH:34]=[CH:33][CH:32]=[N:31][CH:30]=2)=[CH:23][CH:22]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][O:20][C:21]2[CH:22]=[CH:23][C:24]([NH:27][C:28]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)=[O:35])=[CH:25][CH:26]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

Participants

4

Reactant 3

HCID 571860HCID 571860, compoundHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

Product 1

HCID 58822795HCID 58822795, compound

Procedure

The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and N-(4-hydroxy-phenyl)-nicotinamide via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a white solid. MS (ES) for C24H24N2O6 [M+H]+: 437.3.

Workup

  1. customto produce a white solid

Sources & evidence

ORD record
ord-448b81eae1ae4b4aba4887faefae3900
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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