3-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester → 2-Ethoxy-3-(4-hydroxy-phenyl)-propionic acid methyl ester

HRID 459396Notes

Reaction equation

HRID 459396 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH:4]([O:20][CH2:21][CH3:22])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[CH:8][CH:7]=1.COC(=O)C(OC)CC1C=CC=C(O)C=1>>[CH3:1][O:2][C:3](=[O:23])[CH:4]([O:20][CH2:21][CH3:22])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 219309623-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl esterHCID 588228023-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl ester

Product 1

HCID 149239942-Ethoxy-3-(4-hydroxy-phenyl)-propionic acid methyl ester

Procedure

The title compound was prepared from 3-(4-benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester (example 375, Step 3) via the same procedure used for the preparation of 3-(3-hydroxy-phenyl)-2-methoxy-propionic acid methyl ester (Example 291, Step 4) to produce a yellow oil. MS (ES) for C12H16O4 [M+H]+: 225.2, [M+NH4]+: 242.2, [M+Na]+: 247.2.

Workup

  1. customto produce a yellow oil

Sources & evidence

ORD record
ord-301db279e78b425d98c34b06b19a46ad
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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