3-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl ester → (S)-3-(4-hydroxy-phenyl)-2-propoxy-propionic acid ethyl ester

HRID 459399Notes

Reaction equation

HRID 459399 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[C@@H:5]([O:21][CH2:22][CH2:23][CH3:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2].COC(=O)C(OC)CC1C=CC=C(O)C=1>>[CH2:1]([O:3][C:4](=[O:25])[C@@H:5]([O:21][CH2:22][CH2:23][CH3:24])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 588228023-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl esterHCID 58822945(2S)-3-(4-benzyloxy-phenyl)-2-propoxy-propionic acid ethyl ester

Product 1

HCID 58822755(S)-3-(4-hydroxy-phenyl)-2-propoxy-propionic acid ethyl ester

Procedure

The title compound was prepared from (2S)-3-(4-be yloxy-phenyl)-2-propoxy-propionic acid ethyl ester (Example 377, Step 3) via the same procedure used for the preparation of 3-(3-hydroxy-phenyl)-2-methoxy-propionic acid methyl ester (Example 291, Step 4) to produce a yellow oil. MS (ES) for C14H20O4 [M+H]+: 253.1.

Workup

  1. customto produce a yellow oil

Sources & evidence

ORD record
ord-e148863d2691420882b2f1d27e95f561
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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