3-(3-Benzyloxy-phenyl)-2-ethoxy-3-hydroxy-propionic acid ethyl ester → 3-(3-Benzyloxyphenyl)-2-ethoxyacrylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH:5]([O:22][CH2:23][CH3:24])[CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=1)O)[CH3:2].COC(=O)C(OC)=CC1C=CC=C(OCC2C=CC=CC=2)C=1>>[CH2:1]([O:3][C:4](=[O:25])[C:5]([O:22][CH2:23][CH3:24])=[CH:6][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:9]=1)[CH3:2]Participants
3
Procedure
The title compound was prepared from 3-(3-benzyloxy-phenyl)-2-ethoxy-3-hydroxy-propionic acid ethyl ester (Example 378, Step 1) via the same procedure used for the preparation of 3-(3-benzyloxy-phenyl)-2-methoxy-acrylic acid methyl ester (Example 291, Step 2) to afford the title compound as a colorless oil.
Sources & evidence
- ORD record
- ord-ebd41cf370c34d77be992efd0332bb72
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07192982B2
Reaction notes
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