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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459494Generated: October 29, 2026

Water → HCID 23712813, compound

https://huagongshe.com/reaction/459494

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantLithium HydroxideHCID 3939—
ReactantEthyl 1-isopropylpiperidine-4-carboxylateHCID 19900430—
SolventTetrahydrofuranHCID 8028—
ProductHCID 23712813HCID 23712813100%

Reaction Steps

Ethyl 1-isopropylpiperidine-4-carboxylate (Farmaco., 1993, Vol. 48, p. 1439) (3.43 g) was dissolved in tetrahydrofuran (60 ml), and water (15 ml) and lithium hydroxide (421 mg) were added at room temperature to stir the mixture overnight. The reaction mixture was concentrated under reduced pressure to obtain the title compound (3.05 g) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192968B2
Source datasetuspto-grants-2007_03
ORD IDord-d343047cab2a490991646e4f47ef370c
Source noteuspto-grants-2007_03