反应详情

2-(4-Ethoxycarbonylphenyl)pyridine N-oxide (260 mg) synthesized from 4-(2-pyridyl)benzoic acid in the same manner as in the above Referetnial Example was dissolved in 1,4-dioxane (10 ml), a 1N aqueous solution (2.00 ml) of sodium hydroxide was added, and the mixture was heated under reflux for 2 hours. The reaction mixture was concentrated under reduced pressure, 1N hydrochloric acid (6 ml) was added to the residue, and precipitate formed was collected by filtration to obtain the title compound (202 mg) as a colorless amorphous solid.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours
3. concentrationThe reaction mixture was concentrated under reduced pressure, 1N hydrochloric acid (6 ml)
4. additionwas added to the residue, and precipitate
5. customformed
6. filtrationwas collected by filtration