Potassium Carbonate → HCID 178436367, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-Bromomethyl-4-methyl-2,3,5,6-tetrafluorobenzene	HCID 2778368	—
Reactant	N-(4-Ethylbenzyl)-1H-benzo[d]imidazol-5-amine	HCID 67443948	—
Product	HCID 178436367	HCID 178436367	—

Reaction Steps

The compound was synthesized starting from N-(4-ethylbenzyl)benzimidazol-5-amine (251 mg; 1 mmol; 1 eq.), 2,3,5,6-tetrafluoro-4-methylbenzylbromide (283 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.051 g (11.9%); MS m/z: 428.4 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.11 (t, 3H, 3J=7.6 Hz); 2.18 (s, 3H); 2.50-2.54 (m, 2H); 4.47 (s, 2H); 4.70 (s, 2H); 6.87-6.91 (m, 2H); 7.07 (d, 2H, 3J=7.9 Hz); 7.14 (d, 2H, 3J=7.9 Hz); 7.37 (d, 1H, 3J=8.9 Hz), 7.96 (s, 1H); 12.05 (br s, 1H); HPLC (METHOD [A]): rt 19.03 min (93.3%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541596B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-f15a25bacab142a198de5cdc2110b336
Source note	uspto-grants-2013_09