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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459594Generated: October 30, 2026

Hydrochloric Acid → HCID 67187113, compound

https://huagongshe.com/reaction/459594

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantLithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 23704331—
ReactantHCID 58822083HCID 58822083—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 67187113HCID 67187113—

Reaction Steps

(1S,2R,4S)-N2-(tert-Butoxycarbonyl)-4-[N-(tert-butyl)carbamoyl]-N1-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine was treated with a 4N dioxane solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192968B2
Source datasetuspto-grants-2007_03
ORD IDord-9993755bc4424f4b9b1111a0fe5c4e44
Source noteuspto-grants-2007_03