Potassium Carbonate → HCID 178436366, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3,4,5-Trifluorobenzyl bromide	HCID 2777062	—
Reactant	N-(4-Ethylbenzyl)-1H-benzo[d]imidazol-5-amine	HCID 67443948	—
Product	HCID 178436366	HCID 178436366	—

Reaction Steps

The compound was synthesized starting from N-(4-ethylbenzyl)benzimidazol-5-amine (251 mg; 1 mmol; 1 eq.), 3,4,5-trifluorobenzylbromide (248 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.078 g (19.7%); MS m/z: 396.2 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.14 (t, 3H, 3J=7.6 Hz); 2.55 (q, 2H, 3J=7.6 Hz); 4.64 (s, 2H); 4.66 (s, 2H); 6.71-6.74 (m, 2H); 7.13-7.20 (m, 6H); 7.35 (d, 1H, 3J=8.2 Hz); 7.94 (s, 1H); 12.03 (br s, 1H); HPLC (METHOD [A]): rt 18.63 min (92.1%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541596B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-9865d78d088445ff9c5b25725dc7b8ef
Source note	uspto-grants-2013_09