Water → HCID 86597874, compound

Participants

Reaction Steps

To a solution of di-tert-butyl [2-(5-amino-1-methyl-1H-pyrazol-4-yl)-1,3-propanediyl]biscarbamate (1.27 g) in methylene chloride (10 ml) were added 1,8-diazabicyclo[5.4.0]undec-7-ene (1.05 g) and trityl chloride (1.44 g) at room temperature. The mixture was stirred for 2 hours. Water was added and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:1) to give di-tert-butyl {2-[1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]-1,3-propanediyl}biscarbamate (1.7 g).

Provenance & Evidence