Potassium Carbonate → N-(4-Ethylbenzyl)-N-((benzo[d]thiazol-2-yl)methyl)-1H-benzo[d]imidazol-5-amine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-(Bromomethyl)-1,3-benzothiazole	HCID 2776258	—
Reactant	N-(4-Ethylbenzyl)-1H-benzo[d]imidazol-5-amine	HCID 67443948	—
Product	N-(4-Ethylbenzyl)-N-((benzo[d]thiazol-2-yl)methyl)-1H-benzo[d]imidazol-5-amine	HCID 178436369	—

Reaction Steps

The compound was synthesized starting from N-(4-ethylbenzyl)benzimidazol-5-amine (251 mg; 1 mmol; 1 eq.), (benzo[d]-thiazol-2-yl)methylbromide (251 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.118 g (29.6%);; MS m/z: 399.4 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.14 (t, 3H, 3J=7.6 Hz); 2.56 (q, 2H, 3J=7.6 Hz); 4.74 (s, 2H); 5.02 (s, 2H); 6.85-6.86 (m, 2H); 7.15-7.17 (m, 2H); 7.26-7.27 (m, 2H); 7.36-7.39 (m, 2H); 7.46-7.49 (m, 1H); 7.94-7.95 (m, 2H), 7.98-8.00 (m, 1H); 11.98 (br s, 1H); HPLC (METHOD [A]): rt 17.02 min (97.8%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541596B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-6d104f953ae4490796001a36d84d62e5
Source note	uspto-grants-2013_09