Diethyl Ether → di-tert-butyl 7-[({[1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]amino}carbonyl)amino]-6,8-dioxo-2,5,9,12-tetraazatridecanedioate

Participants

Reaction Steps

To a suspension of phenyl N-[1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]carbamate (949 mg) and di-tert-butyl 7-amino-6,8-dioxo-2,5,9,12-tetraazatridecanedioate (968 mg) in dehydrated chloroform (4 ml) was added N-ethyldiisopropylamine (0.342 ml), and the mixture was stirred under reflux for 5 hours. To the reaction mixture was added diethyl ether. The resulting precipitate was collected by filtration and dried in vacuo to give di-tert-butyl 7-[({[1-methyl-5-(tritylamino)-1H-pyrazol-4-yl]amino}carbonyl)amino]-6,8-dioxo-2,5,9,12-tetraazatridecanedioate (1.38 g) as a solid.

Provenance & Evidence