Hydrochloric Acid → HCID 69107744, compound

Participants

Reaction Conditions

Reaction Steps

In a three necked 100 ml flask a suspension of trans-2,6,6-trimethyl-3-cyclohexene-1-carboxylic acid obtained in example 2 a) (0.800 g, 4.8 mmol), ethylbromide (0.616 g, 5.7 mmol) and K2CO3 (0.787 g, 5.7 mmol) in DMF (20 ml) was stirred at 40° C. for 2 h. The cooled reaction mixture was next poured onto cold 5% aqueous HCl and extracted twice with pentane. The organic phases were washed (three times with H2O and brine), dried (Na2SO4), filtered and concentrated. A bulb-to-bulb distillation (100°/4 mbar) afforded 0.870 g of ethyl trans 2,6,6-trimethyl-3-cyclohexene-1-carboxylate in the form of a trans/cis=96:4 mixture (yield=84%).

Provenance & Evidence