関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 2'-Fluoro-4'-methoxyacetophenone | HCID 592821 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | HCID 178487565 | HCID 178487565 | — |
反応手順
100 g of 2-fluoro-4-methoxy-acetophenone in 400 mL of ethylene glycol was stirred at room temperature with hydrazine (0.624 mol, 20 g) for 4 h after which the reaction mixture was heated to 150° C. for 48 h. TLC analysis indicated complete reaction. Partitioned the reaction mixture into dichloromethane and brine. Dried organic phase over sodium sulphate and evaporated to a solid. Re-crystallized from hexane/dicholomethane gave 6-methoxy-3-methyl-1H-indazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196082B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-c7c662a2695e4ba1ba042bf7b82a8947 |
|---|
| 出典メモ | uspto-grants-2007_03 |
|---|
