反应详情

100 g of fluoro-acetophenone in 400 mL of ethylene glycol was stirred at room temperature with hydrazine (0.624 mol, 20 g) for 4 h after which the reaction mixture was heated to 150 C for 48 h. TLC analysis indicated complete reaction. Partitioned the reaction mixture into dichloromethane and brine. Dried organic phase over sodium sulphate and evaporated to a solid. Re-crystallized from hexane/dicholomethane gave indazole.

1. temperaturewas heated to 150 C for 48 h
2. customreaction
3. customPartitioned the reaction mixture into dichloromethane and brine
4. customDried organic phase over sodium sulphate and evaporated to a solid