HRID459739

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1046

Pyrazinamide

C5H5N3O

结构：OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O

HCID440995

(+)-Lactose

C12H22O11

HCID16051971

未命名化合物

$结构：CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C$

HCID135398735

Rifampicin

C43H58N4O12

PRODUCTS

生成物

HCID3767

Isoniazid

C6H7N3O

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.

WORKUP

后处理

customPass the wet mass through multimill and dry the granules at 50–60° C
customPass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60
additionmix with dried granules and isoniazid delayed release powder