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HRID459805

反应详情

EQUATION

反应方程式

HRID 459805 的结构方程式

REACTANTS

反应物

2
结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：CC(C)(C)OC(=O)N1CCN(c2c(F)ccc3c2CNC(=O)N3Cc2ccccc2)CC1
HCID58824135

未命名化合物

PRODUCTS

生成物

1
结构：O=C1NCc2c(ccc(F)c2N2CCNCC2)N1Cc1ccccc1
HCID11163606

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.Cl
溶剂HCID21887872

未命名化合物

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

4-(1-Benzyl-6-fluoro-2-oxo-1,2,3,4-tetrahydro-quinazolin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester (141 mg) was dissolved in 4 mL 2 N HCl/ethanol and heated to 80° C. for 20 minutes, then cooled to room temperature. Diethyl ether was added, precipitating 115 mg of 1-benzyl-6-fluoro-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one hydrochloride. MP: 285.6–290.0° C. MS: 341 (M+H)+.

WORKUP

后处理

  1. temperaturecooled to room temperature
  2. customprecipitating 115 mg of 1-benzyl-6-fluoro-5-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one hydrochloride