HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isocyanato-1-methoxy-4-methylbenzene → Methyl {8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-1-piperazinyl]-3-[6-methoxy-3-methylphenyl]-3,4-dihydro-4-quinazolinyl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isocyanato-1-methoxy-4-methylbenzene | HCID 4141520 | — |
| Reactant | Methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate | HCID 11983908 | — |
| Reactant | 1-(4-Fluoro-3-methylphenyl)piperazine | HCID 19911447 | — |
| Product | Methyl {8-fluoro-2-[4-(4-fluoro-3-methylphenyl)-1-piperazinyl]-3-[6-methoxy-3-methylphenyl]-3,4-dihydro-4-quinazolinyl}acetate | HCID 58824068 | — |
Reaction Steps
Starting with 0.60 g (1.76 mmol) of the iminophosphorane from Example 10A, 376 mg (2.31 mmol) of 2-methoxy-5-methylphenyl isocyanate and 342 mg (1.76 mmol) of the phenylpiperazine from Example 13A, 183 mg (16% of theory) of product are obtained after purification by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196086B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-89ac381b691b4c368929f4b028a11acd |
| Source note | uspto-grants-2007_03 |