HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → HCID 69352330, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1,1-Dimethylethyl 4-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1-piperazinecarboxylate | HCID 21070947 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 69352330 | HCID 69352330 | — |
Reaction Steps
4-(1,2,3,4-Tetrahydroisoquinolin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester as a viscous oil (150 mg) from Step 3 was reacted with benzenesulfonyl chloride (60 microliters) using the Schotten-Baumann procedure (50 mL diethyl ether (Et2O) and 50 mL aqueous sodium carbonate). The ether layer was separated, dried over MgSO4, and concentrated in vacuo. The residue was chromatographed to provide 1.76 mg of 4-(2-benzenesulfonyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196088B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-ccaec0c67ffe429a8212a12560212e66 |
| Source note | uspto-grants-2007_03 |