Benzylamine → 2-benzyl-5-nitroisoquinolin-1(2H)-one

Participants

Reaction Conditions

Reaction Steps

5-Nitro-isochromen-1-one (1.0 g, 5.23 mmol) from step 2 was dissolved in excess benzylamine (5 mL) and heated to 80° C. for 4 hours. The mixture was then diluted in diethyl ether and washed several times with (0.5 N) HCl. The organic layer was concentrated in vacuo to give 2-benzyl-5-nitro-2H-isoquinolin-1-one as a yellow solid.

Provenance & Evidence