tert-Butyl piperazine-1-carboxylate → HCID 22930981, compound

HRID 459842Notes

Reaction equation

HRID 459842 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]=[C:15]([C:17]([OH:19])=O)[CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[C:20]([O:24][C:25]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]=[C:15]([C:17]([N:30]3[CH2:29][CH2:28][N:27]([C:25]([O:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:26])[CH2:32][CH2:31]3)=[O:19])[CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 220219686-(3,4-Dimethoxyphenyl)pyridine-2-carboxylic acid

Product 1

HCID 22930981HCID 22930981, compound

Procedure

Using 6-(3,4-dimethoxyphenyl)pyridine-2-carboxylic acid and t-butoxycarbonylpiperazine, 1-{[6-(3,4-dimethoxyphenyl)pyridine-2-carbonyl]-4-(t-butoxycarbonyl) piperazine was obtained in a similar manner to Example 2 to be mentioned below. Further, a 4M hydrogen chloride/ethyl acetate solution was added thereto and the whole was reacted to obtain an objective compound.

Sources & evidence

ORD record
ord-4cc5e142ce5d4293b4644158344ca33b
Source dataset
uspto-grants-2007_03
Patent number
US07196080B2

Reaction notes

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