HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphonoacetate → HCID 69159682, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphonoacetate | HCID 13345 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate | HCID 2795509 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69159682 | HCID 69159682 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a mixture of 60% sodium hydride and THF were added dropwise ethyl diethylphosphonoacetate and further 4-[4-(t-butoxycarbonyl)piperazin-1-yl]benzaldehyde under cooling to 0° C., followed by stirring. Then, post-treatment and purification were carried out in a usual way to obtain ethyl 3-{4-[4-(t-butoxycarbonyl)piperazin-1-yl]phenyl}acrylate. Further, catalytic reduction was carried out using palladium/carbon to obtain an objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196080B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-51128d431a774e828a5c7c31af85aa11 |
| Source note | uspto-grants-2007_03 |