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(3-(Ethoxycarbonyl)propyl)triphenylphosphonium Bromide → HCID 69161937、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3-(Ethoxycarbonyl)propyl)triphenylphosphonium Bromide | HCID 2773643 | — |
| 反応物 | Tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate | HCID 2795509 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 69161937 | HCID 69161937 | — |
反応手順
4-[4-(t-Butoxycarbonyl)piperazin-1-yl]benzaldehyde and [3-(ethoxycarbonyl)propyl]triphenylphosphonium bromide were reacted in THF in the presence of potassium t-butoxide to obtain ethyl 5-{4-[4-(t-butoxycarbonyl)piperazin-1-yl]phenyl}-4-pentenoate, which was then subjected to catalytic reduction using palladium/carbon to obtain an objective compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196080B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-7bfa364b49774e7daeb68f71c25a4290 |
| 出典メモ | uspto-grants-2007_03 |