HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459852Generated: October 30, 2026
2-(Dimethylamino)ethanol → 2-[(5-Bromo-2-pyridinyl)oxy]-N,N-dimethylethanamine
https://huagongshe.com/reaction/459852
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| Reactant | 2,5-Dibromopyridine | HCID 69353 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[(5-Bromo-2-pyridinyl)oxy]-N,N-dimethylethanamine | HCID 23299638 | — |
Reaction Steps
Potassium t-butoxide was added to a DMF solution of 2,5-dibromopyridine and 2-(dimethylamino)ethanol, and the whole was stirred at an oil bath temperature of 100° C. for 3 hours to obtain N-{2-[(5-bromopyridin-2-yl)oxy]ethyl}—N,N-dimethylamine, which was further treated in a similar manner to Reference Examples 11 and 12 to obtain an objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07196080B2 |
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| Source dataset | uspto-grants-2007_03 |
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| ORD ID | ord-c54482937ad544f5aa6ea461616e30d6 |
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| Source note | uspto-grants-2007_03 |
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