HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluoronitrobenzene → (2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | 2,5-Dimethylpiperazine, trans- | HCID 220672 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine | HCID 57664370 | — |
Reaction Steps
An NMP solution of fluoro-4-nitrobenzene and (±)-trans-2,5-dimethylpiperazine was stirred at an oil bath temperature of 120° C. for 3 hours to obtain (±)-trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine, which was further treated in a similar manner to Example 4 to obtain an objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196080B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-eefa40e2896a40478a7d6d15383254f5 |
| Source note | uspto-grants-2007_03 |