Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 459857Generated: October 30, 2026

Formaldehyde → HCID 18444288, compound

https://huagongshe.com/reaction/459857

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantTetrahydrofuranHCID 8028—
ReactantSodium triacetoxyborohydrideHCID 5049666—
ReactantHCID 18444287HCID 18444287—
SolventAcetic AcidHCID 176—
ProductHCID 18444288HCID 18444288—

Reaction Steps

To a THF solution of ethyl 4-[N-(4-{4-[6-(3,4-dimethoxyphenyl)pyridine-2-carbonyl]piperazin-1-yl}phenyl)amino]butanoate were added a 36% aqueous formalin solution, acetic acid and sodium triacetoxyborohydride, followed by stirring. Then, post-treatment and purification were carried out in a usual way to obtain ethyl 4-[N-(4-{4-[6-(3,4-dimethoxyphenyl)pyridine-2-carbonyl]piperazin-1-yl}phenyl)-N-methylamino]butanoate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07196080B2
Source datasetuspto-grants-2007_03
ORD IDord-f3122cbda60543cfbc9e9bf8aacc98a9
Source noteuspto-grants-2007_03