Hydrochloric Acid → HCID 69161761, compound

Participants

Reaction Steps

To 233 mg of ethyl [(4-{4-[6-(3,4-dimethoxyphenyl)pyridine-2-carbonyl]piperazin-1-yl}benzoyl)amino]acetate was added 0.8 ml of conc. hydrochloric acid, followed by overnight stirring at room temperature. After the reaction solution was concentrated under reduced pressure, crystallization was carried out from 2-propanol-diisopropyl ether to collect [(4-f4-[6-(3,4-dimethoxyphenyl)pyridine-2-carbonyl]piperazin-1-yl}benzoyl)amino]acetic acid hydrochloride by filtration. The filtrate was concentrated under reduced pressure, and the residue was crystallized from hexane to obtain 88 mg of [(4-{4-[6-(3,4-dimethoxyphenyl)pyridine-2-carbonyl]piperazin-1-yl}benzoyl)amino]acetic acid hydrate as pale brown crystals.

Provenance & Evidence