反应详情

Combine 3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-one (Aldrich, 750 mg, 3.78 mmol) with polymer-supported borohydride (Aldrich, 3026 mg, 7.56 mmol) in methanol (30 mL). Shake by rotation the resulting mixture overnight. Filter the reaction mixture and concentrate the filtrate. Wash the residue with hydrochloric acid 0.1M and extract with EtOAc. Dry the organic layer over sodium sulfate, filter and concentrate.

1. customthe resulting mixture overnight
2. filtrationFilter the reaction mixture
3. concentrationconcentrate the filtrate
4. washWash the residue with hydrochloric acid 0.1M
5. extractionextract with EtOAc
6. dry with materialDry the organic layer over sodium sulfate
7. filtrationfilter
8. concentrationconcentrate