関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate | HCID 23019443 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(Piperidin-4-yloxy)benzonitrile hydrochloride | HCID 17832273 | 96% |
反応手順
Add dropwise acetyl chloride (2.5 mL) to methanol (5.0 mL) at 0° C. Stir the resulting solution at 0° C. for 90 min. Then add a solution of 4-(4-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (284 mg, 0.94 mmol) in methanol. Stir the resulting mixture for 3 h. Evaporate the solvent and triturate with diethyl ether to provide the title compound (216 mg, 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196100B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-494f68581f2d484bbc465e010094f0fe |
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| 出典メモ | uspto-grants-2007_03 |
|---|
