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Benzaldehyde → 4-(1-Benzyl-piperidin-4-yloxy)-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 4-(Piperidin-4-yloxy)benzonitrile hydrochloride | HCID 17832273 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(1-Benzyl-piperidin-4-yloxy)-benzonitrile | HCID 11266328 | 95% |
反応手順
Combine 4-(piperidin-4-yloxy)-benzonitrile hydrochloride (64 mg, 0.268 mmol), benzaldehyde (55 μL, 0.536 mmol) and sodium triacetoxy borohydride (85 mg, 0.402 mmol) in CH2Cl2 (3 mL). Stir at room temperature overnight. Dilute the reaction mixture with CH2Cl2 (3 mL) and wash with NaOH (1M aq. 5 mL). Separate the organic layer and place it in an SCX column, eluting with ammonia (2.0M in methanol) to provide the title compound (74 mg, 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196100B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-3a0e7436286b4c1089f4e4737f0fef18 |
| 出典メモ | uspto-grants-2007_03 |