反应详情

A suspension of 115 g (0.49 mol) of 2,6-difluoro-3,5-dimethoxy benzoic acid methyl ester and 42.9 g (1.07 mol) of solid sodium hydroxide in 1.4 L of anhydrous ethanol was refluxed for 24 hours. The ethanol was concentrated in vacuo and the solid residue was dissolved in water and extracted two times with ethyl ether. The aqueous layer was acidified with concentrated hydrochloric acid and a white precipitate was filtered, washed with cold water and dried in vacuo to give 87.9 g (81%) of the title compound. MS (APCI) (m+1)/z 219.1.

1. temperaturewas refluxed for 24 hours
2. concentrationThe ethanol was concentrated in vacuo
3. dissolutionthe solid residue was dissolved in water
4. extractionextracted two times with ethyl ether
5. filtrationa white precipitate was filtered
6. washwashed with cold water
7. customdried in vacuo