Cyclopentyl-{5-[(3-ethoxy-2,6-difluoro-phenylimino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-amine → Cyclopentyl-{5-[(3-ethoxy-2,6-difluoro-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-amine

Participants

Reaction Conditions

Reaction Steps

A solution of 8.00 g (20.4 mmol) cyclopentyl-{5-[(3-ethoxy-2,6-difluoro-phenylimino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl }-amine prepared above, in 200 mL dry THF, was cooled in an ice / water bath. To the cooled solution was added dropwise 1 equivalent (20.4 m, 20.4 mmol) of a 1 M LAH solution in THF. The reaction was stirred cold for 4.5 hours and then warmed to 50° C. for 3.5 hours. The reaction was cooled to room temperature, treated with another 0.5 equivalent (11.0 mL, 11.0 mmol) of 1 M LAH solution in THF, and stirred at room temperature overnight. The reaction was quenched by sequential addition of 1.3 mL water, followed by 5.2 mL of 15% NaOH solution, and finally 2.9 mL of water. The reaction was filtered through Celite and the filter pad was washed well with THF. The THF filtrate was concentrated in vacuo. The residue was dissolved in dichloromethane, washed with a saturated solution of NaCl, and concentrated in vacuo to give 8.03 g (100%) of the title compound as a waxy solid: MS (APCI) (m+1)/z 395.1. Analysis calculated for C19H24F2N4SO: C, 57.85; H, 6.13; N, 14.20. Found: C, 57.92; H, 6.19; N, 14.01.

Provenance & Evidence