Sodium Hydroxide → tert-Butyl 4-(aminomethyl)-4-(4-cyclopropylpiperazin-1-yl)-piperidine-1-carboxylate

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Reaction Steps

To a solution of tert-butyl 4-(4-cyclopropylpiperazin-1-yl)-4-((2,2,2-trifluoroacetamido)methyl)piperidine-1-carboxylate (3.22 mmol) in methanol (8 ml) was added 1 N NaOH solution (13 ml) and the reaction mixture was stirred at room temperature for 2 h. After completion the reaction mixture was extracted with ethyl acetate (3×). The combined organic layers were washed with brine, dried over sodium sulfate and the solvent was evaporated under reduced pressure to obtain the desired product. Yield: 90%.

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