Trifluoroacetic acid → HCID 10414747, compound

Participants

Reaction Steps

To a solution of 4-[7-Amino-3-(2,6-difluoro-3,5-dimethoxy-phenyl)-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (295 mg, 0.567 mmol) in dichloromethane (5 mL) at 0° C. trifluoroacetic acid (647 μL) was added. The resulting solution was stirred at room temperature for 5 hours. The solution was then concentrated under reduced pressure. The resulting residue was concentrated with toluene (2×50 mL) to give a thick oil. Dichloromethane (2 mL) was added to the oil to produce a white precipitate. To accelerate precipitation diethyl ether (10 mL) was added. The mixture was then filtered to deliver 338 mg (92%) of the title compound as a white powder: mp 200° C.–220° C. (decomposition); MS (APCI) 421.1, 422.2.

Provenance & Evidence