HCID 18445054, compound → HCID 10456178, compound

Participants

Reaction Conditions

Reaction Steps

A flask was charged with 0.312 g (0.79 mmol) of 1-Ethyl-3-(2-fluoro-3,5-dimethoxy-phenyl)-7-methanesulfinyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one, 15 mL dioxane, and 0.273 g (2.37 mmol) of trans-4-Aminocyclohexanol, and the mixture was heated 48 hours at 95° C. The dioxane was removed under reduced pressure, and the crude residue was purified directly via column chromatography (20:1 dichloromethane/methanol). This procedure gave 0.215 g (66%) of 1-Ethyl-3-(2-fluoro-3,5-dimethoxy-phenyl)-7-(4-hydroxy-cyclohexylamino)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one as a white solid: mp=198° C.–204° C.; MS (APCI) m+1/z 462.

Provenance & Evidence