Trifluoroacetic acid → HCID 86590950, compound

Participants

Reaction Steps

3-(2,6-Difluoro-3,5-dimethoxy-phenyl)-7-methylamino-1-piperidin-4-yl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one; compound with trifluoroacetic acid was synthesized in the same manner as 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-7-methylamino-1-piperidin-4-yl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one, compound with trifluoroacetic acid; however, 4-[3-(2,6-difluoro-3,5-dimethoxy-phenyl)-7-methylamino-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (411 mg, 0.187 mmol) and trifluoroacetic acid (878 μL) were used to deliver the title compound (482 mg) as a white solid: HPLC=88% pure; mp 135° C.–140° C.; MS (APCI) 435.1, 436.1.

Provenance & Evidence