Acetic Acid → 2-((4-(4-Cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isoindolin-1-one

Participants

Reaction Steps

Through a solution of 2-((1-Benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)isoindolin-1-one (0.63 mmol) in ethanol (10 ml) was passed argon gas for 10 min. Then acetic acid (200 μl) and Pd(OH)2 (20% by weight) were added to the reaction mixture. The mixture was stirred at room temperature for 16 h under an atmosphere of H2 by using a hydrogen balloon. The reaction mixture was filtered through celite and the filtrate was concentrated to dryness to give the desired product. Yield: 60%.

Provenance & Evidence