2-Methoxyethanol → HCID 14795651, compound

HRID 460004Notes

Reaction equation

HRID 460004 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][OH:5].[Cl:6][CH:7]([O:9][C:10](Cl)=[O:11])[CH3:8]>C(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:10](=[O:11])[O:9][CH:7]([Cl:6])[CH3:8]

Participants

4

Reactant 2

HCID 80192-MethoxyethanolHCID 5213051-Chloroethyl chloroformate

Product 1

HCID 14795651HCID 14795651, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 11.9 ml 2-Methoxy-ethanol and 17.98 ml 1-chloroethyl-chloroformate in 200 ml absolute CH2Cl2 13.3 ml pyridine were added at 5–10 ° C. in an argon atmosphere. The mixture was stirred at RT for 5 h and washed successively with 1 N HCl, with an aqueous solution of KHSO4/K2SO4 and water. The organic phase was dried over Na2SO4. After filtration, the solvent was removed in vacuo and the residue purified by destillation. Kp.=88° C. (5.5 mbar). Yield: 22.4 g.

Workup

  1. washwashed successively with 1 N HCl, with an aqueous solution of KHSO4/K2SO4 and water
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationAfter filtration
  4. customthe solvent was removed in vacuo
  5. customthe residue purified by destillation
  6. custom=88° C. (5.5 mbar)

Sources & evidence

ORD record
ord-4a3b61047d5a4859a362b4fcad0bc345
Source dataset
uspto-grants-2007_03
Patent number
US07196103B2

Reaction notes

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