HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 1H-Indole-2,4-dicarboxylic acid 4-methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 1H-Indole-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester | HCID 68858739 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 1H-Indole-2,4-dicarboxylic acid 4-methyl ester | HCID 69507140 | — |
Reaction Steps
To a solution of 3.8 g 1H-Indole-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester were dissolved in 100 ml TFA. After 1 h at RT 150 ml toluene were added and the solvents were removed under reduced pressure. The residue was lyophilised after addition of water and acetonitrile. Yield: 2 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196103B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-a25b45ed7b9145c498fd80725359f84a |
| Source note | uspto-grants-2007_03 |