4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one → HCID 20801186, compound

HRID 460010Notes

Reaction equation

HRID 460010 reaction equation
Cl[CH2:2][C:3]1[O:4][C:5](=[O:9])[O:6][C:7]=1[CH3:8].[Cl:10][C:11]1[S:15][C:14]([C:16]2[O:20][N:19]=[C:18]([CH2:21][N:22]3[C:30]4[C:25](=[CH:26][C:27]([C:31]([OH:33])=[O:32])=[CH:28][CH:29]=4)[CH:24]=[C:23]3[C:34](=[O:45])[NH:35][CH:36]3[CH2:41][CH2:40][N:39]([CH:42]([CH3:44])[CH3:43])[CH2:38][CH2:37]3)[CH:17]=2)=[CH:13][CH:12]=1.ClC1C=CC(NC(CN2C3C=CC=C(C(O)=O)C=3C=C2C(=O)NC2CCN(C(C)C)CC2)=O)=NC=1>>[CH3:8][C:7]1[O:6][C:5](=[O:9])[O:4][C:3]=1[CH2:2][O:33][C:31]([C:27]1[CH:26]=[C:25]2[C:30](=[CH:29][CH:28]=1)[N:22]([CH2:21][C:18]1[CH:17]=[C:16]([C:14]3[S:15][C:11]([Cl:10])=[CH:12][CH:13]=3)[O:20][N:19]=1)[C:23]([C:34](=[O:45])[NH:35][CH:36]1[CH2:37][CH2:38][N:39]([CH:42]([CH3:43])[CH3:44])[CH2:40][CH2:41]1)=[CH:24]2)=[O:32]

Participants

4

Reactant 3

HCID 98555184-(Chloromethyl)-5-methyl-1,3-dioxol-2-oneHCID 22394458HCID 22394458, compoundHCID 68561939HCID 68561939, compound

Product 1

HCID 20801186HCID 20801186, compound

Procedure

The title compound was prepared analogously to example 5 with the difference that 4-Chloromethyl-5-methyl-[1,3]dioxol-2-one and 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-indole-5-carboxylic acid was used instead of Carbonic acid 1-chloro-ethyl ester 2-methoxy-ethyl ester and 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-2-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-indole-4-carboxylic acid. MS (ES+): m/e=639, chloro pattern.

Sources & evidence

ORD record
ord-0cc351eae56847418c6e6a2018c606f1
Source dataset
uspto-grants-2007_03
Patent number
US07196103B2

Reaction notes

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