反应详情

A solution of 5-{(E)-2-[4-(benzyloxy)-3-methylphenyl]ethenyl}-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole)_(intermediate 6, 1.5 g) in glacial acetic acid (30 ml) was hydrogenated over 10% palladium on carbon (0.150 g). The catalyst was filtered off, the solvent was removed and the residues dissolved in ethyl acetate. This was washed with saturated sodium bicarbonate solution and brine. Drying and removal of solvent gave an oil which was purified by SPE (Si cartridge). Elution with cyclohexane:ethyl acetate gave the title compound as a white solid.

1. filtrationThe catalyst was filtered off
2. customthe solvent was removed
3. dissolutionthe residues dissolved in ethyl acetate
4. washThis was washed with saturated sodium bicarbonate solution and brine
5. customDrying
6. customremoval of solvent
7. customgave an oil which
8. customwas purified by SPE (Si cartridge)
9. washElution with cyclohexane