HCID 17972196, compound → HCID 17972179, compound

Participants

Reaction Steps

To a solution of (2E)-1-[4-(benzyloxy)-3-methylphenyl]-3-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}prop-2-en-1-one (intermediate 9, 0.77 g) in ethanol (30 ml) and 1,4-dioxane (10 ml) was added to 20% palladium hydroxide (0.31 g) and hydrogenated at 21° C. for 18 hours. The reaction was filtered through Celite and the filtrate evaporated to give material which was further purified by flash column chromatography using cyclohexane:ethyl acetate (3:1) as eluent to give the title compound as a colourless oil.

Provenance & Evidence