Ethyl bromoacetate → HCID 58824789, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(4-hydroxy-3-methylphenyl)-3-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}propan-1-one (intermediate 10, 0.28 g) in dry acetonitrile (15 ml) was treated with ethyl bromoacetate (0.076 ml) and cesium carbonate (0.449 g) and heated at 55° C. for 18 hours. The reaction was filtered, and the filtrate evaporated to give material which was further purified by flash column chromatography using cyclohexane:ethyl acetate (3:1) as eluent to give the title compound as a white solid.

Provenance & Evidence