Sodium borohydride → HCID 86592484, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl [2-methyl-4-(3-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}propanoyl)phenoxy]acetate (intermediate11, 0.28 g) in tetrahydrofuran (8 ml) and water (8 ml) at 0° C. was treated portion-wise with sodium borohydride (0.043 g) and the mixture was stirred at 0° C. for 1 hour. The solvent was evaporated and the residue partitioned between water and ethyl acetate; the aqueous layer was separated and extracted twice more with ethyl acetate. The combined organic solutions were dried with brine and over magnesium sulfate and concentrated. The product isolated after evaporation of the solvent was further purified by flash column chromatography using cyclohexane:ethyl acetate (3:1) as eluent to give the title compound as a colourless gum.

Provenance & Evidence