HCID 9849316, compound → HCID 10227955, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl [4-(1,1-difluoro-3-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}propyl)-2-methylphenoxy]acetate (example 1, 0.028 g) in tetrahydrofuran (4 ml) and 2M aqueous sodium hydroxide (4 ml) was stirred at 60° C. for 2 hours. The solvent was evaporated and the residue partitioned between ether and water; the aqueous layer was acidified using 10% w/v aqueous citric acid and then extracted thrice with ethyl acetate. The combined ethyl acetate solutions were dried over magnesium sulfate and evaporated to give the title compound.

Provenance & Evidence