Cesium carbonate → Methyl 4-[2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenoxy]butanoate

Participants

Reaction Steps

To a solution of 2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol (intermediate 7, 0.08 g ) in acetonitrile (2 ml) was added methyl 4-bromobutyrate (0.090 g) and cesium carbonate (0.194 g). The mixture was stirred at room temperature for 24 hours then partitioned between water and ethyl acetate. The organic layer was dried, the solvent removed and the resulting oil was purified by SPE(Si cartridge). Elution with cyclohexane:ethyl acetate (20:1) gave the title compound as an oil which crystallised on standing.

Provenance & Evidence