Ethyl [2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethenyl)phenoxy]acetate → HCID 16109179, compound

Participants

Reaction Steps

A mixture of ethyl [2-methyl-4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethenyl)phenoxy]acetate (intermediate 19, 0.23 g) and 10% palladium on carbon (0.2 g) in ethanol:1,4-dioxan (1:1, 20 ml) was stirred under a hydrogen atmosphere for 6 hours. The reaction mixture was filtered through Celite™ and the filtrate evaporated. The residue was purified by Biotage™ chromatography using a mixture of petroleum ether:ethyl acetate (4:1) as eluent to give the title compound as a pale yellow solid.

Provenance & Evidence