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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 460071Generated: October 29, 2026

2-(Trifluoromethyl)benzeneboronic acid → 5-Methyl-4-(2'-trifluoromethyl-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid

https://huagongshe.com/reaction/460071

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethyl)benzeneboronic acidHCID 2734387—
Reactant4-(4-Iodo-phenoxymethyl)-5-methyl-furan-2-carboxylic acid methyl esterHCID 58824157—
Product5-Methyl-4-(2'-trifluoromethyl-biphenyl-4-yloxymethyl)-furan-2-carboxylic acidHCID 18444603—

Reaction Steps

Compound (102) was prepared from compound (20) and (2-trifluoromethyl-phenyl)-boronic acid by adapting the procedure of Example 5(b). LC/MS System B; Rt=1.93 mins, m/z (ES−)=375 (M−H for C20H15F3O4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07196089B2
Source datasetuspto-grants-2007_03
ORD IDord-a46d17e5daae47a88982d3ef0ff52004
Source noteuspto-grants-2007_03