2-Methylbenzenesulfonamide → N-(4-[(4'-Difluoromethoxy-biphenyl-4-ylamino)-methyl]-5-methyl-furan-2-carbonyl)-2-methyl-benzenesulphonamide

HRID 460110Notes

Reaction equation

HRID 460110 reaction equation
[F:1][CH:2]([F:27])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH2:17][C:18]3[CH:19]=[C:20]([C:24]([OH:26])=O)[O:21][C:22]=3[CH3:23])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[CH3:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[S:35]([NH2:38])(=[O:37])=[O:36]>>[F:1][CH:2]([F:27])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][CH2:17][C:18]3[CH:19]=[C:20]([C:24]([NH:38][S:35]([C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=4[CH3:28])(=[O:36])=[O:37])=[O:26])[O:21][C:22]=3[CH3:23])=[CH:14][CH:15]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 69242-MethylbenzenesulfonamideHCID 184445644-(4'-Difluoromethoxy-biphenyl-4-ylaminomethyl)-5-methyl-furan-2-carboxylic acid

Product 1

HCID 18444619N-(4-[(4'-Difluoromethoxy-biphenyl-4-ylamino)-methyl]-5-methyl-furan-2-carbonyl)-2-methyl-benzenesulphonamide

Procedure

Compound (173) was prepared from compound (171) and 2-methyl-benzenesulphonamide by adapting the procedure of Example 38(f). LC/MS System D; Rt=10.63 mins, m/z (ES+)=527 (M+H for C27H24F2N2O5S).

Sources & evidence

ORD record
ord-7820eff9f9494c10a1fb0e68e369f4cf
Source dataset
uspto-grants-2007_03
Patent number
US07196089B2

Reaction notes

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